The supreme leader of the Sinaloa Cartel has pleaded guilty to U.S. federal drug charges in connection with leading the most powerful drug cartel in the world. His plea has sparked much speculation in Mexico, where his expected cooperation could implicate some of the country’s highest-ranking political figures.

During a change of plea hearing at a federal courthouse in Brooklyn before U.S. District Judge Brian Cogan, attorneys for Ismael “El Mayo” Zambada entered a guilty plea to racketeering and conspiracy charges as part of an apparent plea deal with prosecutors. He faces a mandatory life sentence.

Earlier this month, federal prosecutors…

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