After House talks imploded this week over the fate of a college athletics bill, senators now believe they have the upper hand in shaping a sweeping package that would enact new rules for a multibillion-dollar industry that has been destabilized by years of political and legal battles.

Sens. Ted Cruz of Texas and Maria Cantwell of Washington, the top Republican and Democrat on the Senate Commerce Committee, have been spending hours every day for the past week at the negotiating table.

“Both of us, I believe, want to get to ‘yes,’” Cruz said in an interview Tuesday. “There’s a real crisis in college sports and if Congress doesn’t act, we are…

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